4,5-dichloro-2-methoxypyridine synthesis
- Product Name:4,5-dichloro-2-methoxypyridine
- CAS Number:688047-08-7
- Molecular formula:C6H5Cl2NO
- Molecular Weight:178.02
72141-44-7
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688047-08-7
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Yield:688047-08-7 73%
Reaction Conditions:
with N-chloro-succinimide in N,N-dimethyl-formamide at 20; for 12 h;
Steps:
1.e
(e); 10.0 g (69.9 mmol) of crude 4-chloro-2-methoxypyridine obtained in Step (d) was dissolved in 100 ml of dimethylformamide, and 37.2 g (279 mmol) of N-chlorosuccinimide was added, followed by stirring at room temperature for 12 hours. 400 ml of water was added to terminate the reaction, followed by extraction with ethyl ether. The organic layer was washed with a saturated sodium chloride solution, dried over sodium sulfate and subjected to filtration, and the solvent was distilled off under reduced pressure to obtain 9.10 g (crude yield: 73%) of crude 4,5-dichloro-2-methoxypyridine. 1H-NMR(CDCl3, 400 MHz) : δ (ppm) = 3.90(s, 3H), 6.85(s, 1H), 8.14(s, 1H)
References:
EP1679003,2006,A1 Location in patent:Page/Page column 13
856965-66-7
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74-88-4
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688047-08-7
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98197-72-9
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851607-23-3
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688047-08-7
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372-48-5
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