4,5-dihydro-2-undecyl-Oxazol synthesis
- Product Name:4,5-dihydro-2-undecyl-Oxazol
- CAS Number:10431-84-2
- Molecular formula:C14H27NO
- Molecular Weight:225.37
Yield:10431-84-2 98%
Reaction Conditions:
with dmap in toluene at 140; for 0.0833333 h;Inert atmosphere;Microwave irradiation;Temperature;
Steps:
General procedure of microwave-assisted synthesis for the synthesis of 2-oxazolines
General procedure: Carboxylic acid (0.3 mmol, 1 equiv.), 2-chloroethyl isocyanates (0.375 mmol, 1.25 equiv.) and 0.6 mmol DMAP (0.6 mmol, 2 equiv.) were added into 3 mL toluene in a 10 mL glass vial under nitrogen atmosphere. Then the tube was then placed into the microwave synthesizer, and the reaction was carried out at 140 for 5 min. After the reaction was complete, the solvent was removed under vacuum. The resulting crude residue was purified by basic alumina column chromatography to give the 2-oxazolines. The 2-oxazolines were further characterized by GC-MS, 1H NMR and 13C NMR.
References:
Zhu, Jipeng;Zhou, Min;Jiang, Weinan;Zhou, Yang;Song, Gonghua;Liu, Runhui [Tetrahedron Letters,2022,vol. 91,art. no. 153637] Location in patent:supporting information
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