4,5-Dimethyl-1,2-oxazol-3-amine hydrochloride synthesis

Yield:-

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane at 20; for 5 h;

Steps:

1.A

A. 4,5-Dimethyl-3-isoxazolamie hydrochloride To (4,5-dimethyl-3-isoxazolyl)carbamic acid 1,1-dimethylethyl ester (25.0 g, 117.79 mmol, prepared as described in Konoike, T. et al.,Tet. Lett., 37, 3339-3342 (1996)) in a flask, 100 ml 4N HCl in dioxane was added. The mixture was stirred at room temperature for 5 hrs and concentrated to give the title product of this step as a solid which was used in the next step without further purification.

References:

EP996618,2003,B1 Location in patent:Page/Page column 5