4,6-Dibromo-5-hydroxypicolinic acid synthesis
- Product Name:4,6-Dibromo-5-hydroxypicolinic acid
- CAS Number:64354-26-3
- Molecular formula:C6H3Br2NO3
- Molecular Weight:296.9
30766-12-2
140 suppliers
$30.44/1g
64354-26-3
16 suppliers
$75.00/250mg
Yield:64354-26-3 67%
Reaction Conditions:
with bromine in water;
Steps:
2 4,6-Dibromo-5-hydroxy-2-pyridinecarboxylic acid, Methyl Ester (Compound No. 2):
EXAMPLE 2 4,6-Dibromo-5-hydroxy-2-pyridinecarboxylic acid, Methyl Ester (Compound No. 2): To a stirred solution of 15 g 5-hydroxypyridine-2-carboxylic acid methyl ester in 300 ml water, 31.2 g bromine was added slowly. The mixture was stirred until disappearance of the bromine color resulted. Then the solid was removed by filtration, washed with cold water, and recrystallized from benzene/hexane (2:3, respectively) in 67% yield; m.p. 148°-150° C. Calc. for C7 H5 Br2 NO3: Br, 51.0. Found: Br, 51.2.
References:
US4025333,1977,A
64354-25-2
15 suppliers
$250.00/250mg
64354-26-3
16 suppliers
$75.00/250mg