4,6-Dichloro-5-MethoxypyriMidin-2-aMine synthesis

Yield: 48%

Reaction Conditions:

with phosphorus pentachloride;N-benzyl-N,N,N-triethylammonium chloride;trichlorophosphate in acetonitrile for 16 h;Reflux;

References:

Altenbach, Robert J.;Adair, Ronald M.;Bettencourt, Brian M.;Black, Lawrence A.;Fix-Stenzel, Shannon R.;Gopalakrishnan, Sujatha M.;Hsieh, Gin C.;Liu, Huaqing;Marsh, Kennan C.;McPherson, Michael J.;Milicic, Ivan;Miller, Thomas R.;Vortherms, Timothy A.;Warrior, Usha;Wetter, Jill M.;Wishart, Neil;Witte, David G.;Honore, Prisca;Esbenshade, Timothy A.;Hancock, Arthur A.;Brioni, Jorge D.;Cowart, Marlon D. [Journal of Medicinal Chemistry,2008,vol. 51,# 20,p. 6571 - 6580] Location in patent:supporting information; experimental part