4-acetyl-1-naphthoic acid synthesis
- Product Name: 4-acetyl-1-naphthoic acid
- CAS Number:131986-05-5
- Molecular formula:C13H10O3
- Molecular Weight:214.22
501441-64-1
15 suppliers
inquiry
131986-05-5
119 suppliers
inquiry
Yield:131986-05-5 91.2%
Reaction Conditions:
with tetrabutylammomium bromide;water;sodium hydroxide in toluene at 65;
Steps:
7 Example 7 Preparation of 4-acetyl-1-naphthoic acid represented by formula (II)
Add compound (7), 4-acetyl-1-naphthoate methyl ester (17g, 74.5mmol) and toluene (170mL) into a 250mL round bottom flask,Stir to dissolve, add water (170mL), NaOH (5.9g, 149mmol), TBAB (4.8g, 14.9mmol),The temperature was raised to 65°C to react overnight, the reaction solution was cooled to room temperature, and the layers were separated, and the aqueous phase was washed with toluene (170 mL). While stirring the aqueous phase at room temperature, slowly add 4mol/L HCl (40mL) dropwise until the solid is completely precipitated, continue stirring for 1h, and filter with suction.After drying, 4-acetyl-1-naphthoic acid was obtained as an off-white solid: 14.5 g, yield 91.2%, purity 98.6%;
References:
CN113354530,2021,A Location in patent:Paragraph 0098-0101
605-70-9
256 suppliers
$8.00/5g
131986-05-5
119 suppliers
inquiry
7487-15-2
46 suppliers
$223.00/1g
131986-05-5
119 suppliers
inquiry
21426-90-4
13 suppliers
inquiry
131986-05-5
119 suppliers
inquiry
90-11-9
544 suppliers
$5.00/10g
131986-05-5
119 suppliers
inquiry