(4-Amino-2-trifluoromethyl-phenyl)-methanol synthesis
- Product Name:(4-Amino-2-trifluoromethyl-phenyl)-methanol
- CAS Number:900254-46-8
- Molecular formula:C8H8F3NO
- Molecular Weight:191.15
![[4-Nitro-2-(trifluoromethyl)phenyl]methanol, 2-(Hydroxymethyl)-5-nitrobenzotrifluoride](/CAS/GIF/859027-06-8.gif)
859027-06-8
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Yield: 83.39%
Reaction Conditions:
with palladium on activated charcoal;hydrogen in methanol at 20;
Steps:
6.9 Step 9. Synthesis of 4-amino-2-(trifluoromethyl)phenyl]methanol, (Cmp.2-i)
To a stirred solution of 4-(hydroxymethyl)-3-(trifluoromethyl)phenylazinic acid (9.10 g, 40.780 mmol, 1.00 equiv) and Pd/C (0.43 g, 4.078 mmol, 0.10 equiv) in MeOH (49.53 mL, 1545.851 mmol, 30.00 equiv) at room temperature under hydrogen atmosphere. The precipitated solids were collected by filtration and washed with MeOH (3x40 mL). The resulting mixture was concentrated under vacuum. This resulted in 4-amino-2- (trifluoromethyl)phenyl]methanol (6.5g, 83.39%as a yellow solid.
References:
ALBERT EINSTEIN COLLEGE OF MEDICINE;GAVATHIOTIS, Evripidis;AGIANIAN, Bogos WO2020/176501, 2020, A1 Location in patent:Paragraph 0151; 0160
5308-25-8
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