4-Amino-3-chlorophenylboronic acid, pinacol ester synthesis
- Product Name:4-Amino-3-chlorophenylboronic acid, pinacol ester
- CAS Number:721960-43-6
- Molecular formula:C12H17BClNO2
- Molecular Weight:253.53
42016-93-3
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$15.00/5g
73183-34-3
593 suppliers
$6.00/5g
721960-43-6
77 suppliers
$41.00/250mg
Yield: 74%
Reaction Conditions:
with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate in 1,4-dioxane at 90; for 12 h;Inert atmosphere;
Steps:
5.1.9. General procedure G: syntheses of compounds 23a-23f
General procedure: The substituted aniline (22ae22f) (10.0 mmol, 1.0 eq), bis(pinacolato)diboron (12.0 mmol, 1.2 eq), potassium acetate(30.0 mmol, 3.0 eq) and PdCl2(dppf) (1.0 mmol, 0.1 eq) were suspendedin 1,4-dioxane (50 mL) under argon atmosphere and thereaction mixture was heated to 90 C for 12 h. The crude mixturewas filtered through a thin plug of Celite. The Celite plug waswashed with ethyl acetate and filtrate was concentrated. Theresulting residue was purified by silica gel chromatography (petroleumether/ethyl acetate, v/v, 98:2) to give the desired product.
References:
Ai, Jing;Duan, Wenhu;Geng, Meiyu;Ji, Yinchun;Peng, Xia;Shen, Yanyan;Sun, Deqiao;Wang, Wei;Xu, Dandan;Zhan, Zhengsheng [European Journal of Medicinal Chemistry,2021,vol. 220,art. no. 113497]
38762-41-3
291 suppliers
$22.00/25g
73183-34-3
593 suppliers
$6.00/5g
721960-43-6
77 suppliers
$41.00/250mg
38762-41-3
291 suppliers
$22.00/25g
25015-63-8
224 suppliers
$22.39/5G
721960-43-6
77 suppliers
$41.00/250mg
95-51-2
399 suppliers
$5.00/5 g
721960-43-6
77 suppliers
$41.00/250mg
95-51-2
399 suppliers
$5.00/5 g
73183-34-3
593 suppliers
$6.00/5g
721960-43-6
77 suppliers
$41.00/250mg
850567-56-5
83 suppliers
$10.00/100mg