7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine synthesis
- Product Name:7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine
- CAS Number:1770840-43-1
- Molecular formula:C6H5IN4
- Molecular Weight:260.04
![PYRROLO[1,2-F][1,2,4]TRIAZIN-4-AMINE](/CAS/GIF/159326-68-8.gif)
159326-68-8
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1770840-43-1
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Yield:1770840-43-1 95%
Reaction Conditions:
with N-iodo-succinimide in N,N-dimethyl-formamide at 0; for 1 h;
Steps:
Synthesis of iodinated intermediates of formula (I) (ie X in formula (I) is iodine):
In a 1000 ml round bottom flask, 40 g of the triazineamine compound of formula (V) obtained above and 200 ml of DMF were added. After the resulting mixture was cooled to 0°C, 70 g of N-iodosuccinimide was added at once, and the reaction was magnetically stirred for 1 hour. After that, the resulting reaction mixture was poured into 500 mL of 1 M NaOH aqueous solution, and a large amount of pale white precipitate was generated. Finally, suction filtration was performed, and the filter residue was washed with water and dried over anhydrous sodium sulfate to obtain a high-purity iodinated intermediate compound of formula (I) (yield: about 95%).
References:
CN111233870,2020,A Location in patent:Paragraph 0062-0063
1003-29-8
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4513-94-4
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![3H-Pyrrolo[2,1-f][1,2,4]triazin-4-one](/CAS/GIF/159326-71-3.gif)
159326-71-3
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1770840-43-1
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![4-chloropyrrolo[1,2-f][1,2,4]triazine](/CAS/GIF/888720-29-4.gif)
888720-29-4
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1770840-43-1
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