4-AMINO-FURAZAN-3-CARBOXYLIC ACID METHYLAMIDE synthesis
- Product Name:4-AMINO-FURAZAN-3-CARBOXYLIC ACID METHYLAMIDE
- CAS Number:30720-84-4
- Molecular formula:C4H6N4O2
- Molecular Weight:142.12
74-89-5
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30720-84-4
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$90.00/1g
Yield:30720-84-4 99%
Reaction Conditions:
in ethanol at 20; for 2.16667 h;Reflux;
Steps:
Scheme 10, Step A:
To ethy1 4-amino-l,2,5-oxadiazole-3-carboxy1ate (2.00 g, 12.5 mmol) is added methy1amine (33% in EtOH, 30 mL, 241 mmol). The mixture is heated to reflux for 10 minutes, then allowed to stir at room temperature for 2 hours. The crude reaction mixture is combined with a separate reaction performed identically on 300 mg scale, and the solution is concentrated in vacuo. The resulting dark brown solid is triturated with MeOH to remove colored impurities. The solid is filtered and washed with 1 : 1 MeOH : diethy1 ether. The solid is dried in a vacuum oven to give the title compound (2.01 g, 99% yield). 1H NMR (MeOD) d 2.92 (s, 3H).
References:
WO2020/146194,2020,A1 Location in patent:Page/Page column 23; 64
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