4-Aminomethyl-3-nitrobenzoic acid synthesis

4synthesis methods

Product Name:4-Aminomethyl-3-nitrobenzoic acid
CAS Number:2372-51-2
Molecular formula:C8H8N2O4
Molecular Weight:196.16

55715-03-2 Synthesis

55715-03-2
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Yield:2372-51-2 1.089 g (72%)

Reaction Conditions:

with ammonia in methanol;

Steps:

3 Preparation of 3-nitro-4-aminomethyl benzoic acid 4b:

EXAMPLE 3 Preparation of 3-nitro-4-aminomethyl benzoic acid 4b: Dry liquid ammonia (15 ml) was added to 2.0 g (7.7 mmol) of 3-nitro-4-bromomethyl benzoic acid 4 in a pressure resistant bottle. The solution was stirred at 0°-5° for 24 hours. The bottle was then cooled to -78° C., opened and the ammonia evaporated. The residue was suspended in methanol, collected by filtration, washed with methanol and dried to give acid 4b: m.p. 235°-237° C., yield 1.089 g (72%).

References:

US4189605,1980,A

Benzoic acid, 4-[[(trifluoroacetyl)amino]methyl]-

130029-61-7
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References

56-91-7 Synthesis

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96-98-0
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$8.00/10g

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References