4-AMINOMETHYLPHENYLACETIC ACID synthesis
- Product Name:4-AMINOMETHYLPHENYLACETIC ACID
- CAS Number:1200-05-1
- Molecular formula:C9H11NO2
- Molecular Weight:165.19
71420-92-3
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1200-05-1
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Yield: 100%
Reaction Conditions:
with chlorotriisopropylsilane;trifluoroacetic acid at 20; for 0.5 h;
Steps:
EXAMPLE. Compound 107.
EXAMPLE. Compound 107. Boc-4-aminomethylphenylacetic acid (106) (2.00g, 7.5 mmol) dissolved in a solution of trifluoroacetic acid (9.75mL) and triisopropylsilane (0.25mL) and stirred at room temperature for 30 min, then concentrated under reduced pressure and coevaporated with dichloromethane (3x), then placed under vacuum, to yield 4- aminomethylphenylacetic acid (107) (quantitative).
References:
ENDOCYTE, INC.;VLAHOV, Iontcho Radoslavov;REDDY, Joseph Anand;BLOOMFIELD, Alicia;DORTON, Ryan;NELSON, Melissa;VETZEL, Marilynn;LEAMON, Christopher Paul WO2014/78484, 2014, A1 Location in patent:Page/Page column 68
5462-71-5
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1200-05-1
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13737-36-5
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$10.40/1G
1200-05-1
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$82.00/100 mg
103-82-2
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$22.19/5g
1200-05-1
59 suppliers
$82.00/100 mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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1200-05-1
59 suppliers
$82.00/100 mg