4-broMo-1,2-bis(broMoMethyl)benzene synthesis
- Product Name:4-broMo-1,2-bis(broMoMethyl)benzene
- CAS Number:69189-19-1
- Molecular formula:C8H7Br3
- Molecular Weight:342.85
171011-37-3
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$120.00/1g
69189-19-1
63 suppliers
$43.00/250mg
Yield: 95%
Reaction Conditions:
with phosphorus tribromide in diethyl ether at 0; for 7 h;Reflux;
Steps:
4-Bromo-1,2-bis(bromomethyl)benzene (12):
To a solution of 11 (103 mg, 0.474 mM) in Et2O (3 mL) was slowly added a solution of PBr3 (0.16 mL,1.66 mM) in Et2O (0.25 mL) at 0 °C. The whole was refluxed for 7 h, poured to ice (ca 30 mL), andextracted with Et2O (20 mL × 3). The organic solutions were washed with brine (10 mL), dried, andevaporated. Purification of the residue by column chromatography (SiO2, hexane) gave 12 (154 mg,95%) as colorless plates, mp 42-44 °C (lit [20]. mp 40-44 °C).
References:
Suzuki, Noriyuki;Kishimoto, Kaito;Yamazaki, Kohei;Kumamoto, Takuya;Ishikawa, Tsutomu;Margetić, Davor [Synlett,2013,vol. 24,# 19,p. 2510 - 2514] Location in patent:supporting information
583-71-1
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$13.43/1gm:
69189-19-1
63 suppliers
$43.00/250mg
86-90-8
295 suppliers
$7.00/5g
69189-19-1
63 suppliers
$43.00/250mg