4-bromo-1-cyclopropyl-1H-pyrazole synthesis
- Product Name:4-bromo-1-cyclopropyl-1H-pyrazole
- CAS Number:1151802-23-1
- Molecular formula:C6H7BrN2
- Molecular Weight:187.04
2075-45-8
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4333-56-6
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1151802-23-1
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Yield: 68%
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide at 180; for 1.5 h;Microwave irradiation;
Steps:
A30.1 Step 1 : 4-Bromo- 1 -cyc
Step 1 : 4-Bromo- 1 -cyc A mixture of 4-bromo-lH-pyrrazole (1.0 g, 6.8 mmol), bromo cyclopropane (1.3 g, 10.7 mmol), cesium carbonate (3.5 g. 10.7 mmol), and DMF (6 mL) in a 30 mL microwave vial is heated to 180 °C under radiation for 1.5 hr. After cooled to room temperature, the reaction mixture is filtered. The filtrate is concentrated and the residue is purified on a silica gel flash chromatography with ethyl acetate/petroleum ether (1 :5) to get a brown liquid (0.87 g, 68% yield). (MS: [M+l] 259)
References:
Location in patent:Page/Page column 14
2075-45-8
392 suppliers
$5.00/5g
411235-57-9
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$6.00/1g
1151802-23-1
91 suppliers
$24.00/100mg
1151814-36-6
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$108.00/100mg
1151802-23-1
91 suppliers
$24.00/100mg