4-BROMO-2,6-BIS(1-METHYLETHYL)BENZENAMINE synthesis

Yield: 100%

Reaction Conditions:

with N-Bromosuccinimide in N,N-dimethyl-formamide at 0 - 5; for 0.333333 h;Inert atmosphere;

Steps:

A solution of NBS (24.59 g, 137 mmol) in DMF (160 mL) was added slowly to a solution of 2,6-diisopropylaniline (25 g, 137 mmol) in DMF (300 mL) at 0-5°C under a nitrogen atmosphere over a period of 20 minutes. The reaction mixture was stirred at 0-5°C. After the reaction was complete, water was added and the oil suspension was stirred at rt. The aqueous layer was decanted out and the remaining oil was dissolved in ethyl acetate. The organic layer was separated, washed water and brine.Evaporation gave light brown oil (35.1 g, 100% yield).

References:

UNIVERSAL DISPLAY CORPORATION;XIA, Chuanjin;YEAGER, Walter;LI, David Zenan;FIORDELISIO, James;MA, Bin;ELSHENAWY, Zeinab;LAYEK, Suman;BARRON, Edward;KOTTAS, Gregg;BROOKS, Jason WO2012/116231, 2012, A2 Location in patent:Page/Page column 120