4-bromo-2,6-dichloropyridine synthesis

Yield:-

Reaction Conditions:

with copper(ll) bromide in Isobutyronitrile;acetonitrile at 0 - 20; for 12 h;

Steps:

17.A
4-bromo-2,6-dichloropyridineTo a suspension of copper (II) bromide (8.2 g) in acetonitrile was added t-butylnitrile (5.5 mL) at O⁰C 4-amino-2,6-dichloropyridne (5.0 g) in acetonitrile. The mixture slowly warmed to room temperature and stirred for an additional 12 h. The mixture was poured into 2N HCl and extracted with ethyl acetate, washed with brine, dried over magnesium sulfate, and concentrated. The title compound was recrystallized from toluene/hexanes (4.5 g).

References:

MERCK & CO., INC. WO2007/21710, 2007, A1 Location in patent:Page/Page column 42

FullText