4-BroMo-2-chloro-1-(chloroMethyl)benzene synthesis
- Product Name:4-BroMo-2-chloro-1-(chloroMethyl)benzene
- CAS Number:185315-49-5
- Molecular formula:C7H5BrCl2
- Molecular Weight:239.92
185315-48-4
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Yield:185315-49-5 74.4%
Reaction Conditions:
with thionyl chloride at 0 - 70; for 1.08333 h;
Steps:
1
Add SOCl2 (164.2 mg, 1.4 mmol, 3.0 eq) in 4-bromo-2-chlorobenzyl alcohol (94.3 mg, 0.4 mmol, 1.0 eq) dropwise at 0° C. After reacting for 5 min,Move to 70°C under reflux, and after stirring for 1h, TLC thin layer chromatography monitors the completion of the reaction and stops stirring.Extracted with ethyl acetate, the pH of the solid NaHCO3 was adjusted to neutral, and then saturated aqueous NaCl,Anhydrous MgSO4 was dried to obtain 81.1mg 4-bromo-2-chlorobenzyl chloride with a yield of 74.4%.
References:
CN111196785,2020,A Location in patent:Paragraph 0053; 0070-0071; 0074
158435-41-7
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