4-Bromo-2-chlorobenzamide synthesis
- Product Name:4-Bromo-2-chlorobenzamide
- CAS Number:426265-73-8
- Molecular formula:C7H5BrClNO
- Molecular Weight:234.48
79-37-8
482 suppliers
$17.67/10gm:
59748-90-2
289 suppliers
$8.00/1g
426265-73-8
44 suppliers
$55.00/250mg
Yield:426265-73-8 87%
Reaction Conditions:
with ammonium hydroxide
Steps:
222.1 Step 1:
Step 1:
4-Bromo-2-chlorobenzamide
To a solution of 4-bromo-2-chlorobenzoic acid (10.0 g, 42.5 mmol) in DCM (100 mL) at 0° C. was added oxalyl chloride (21.5 g, 0.169 mol) portionwise over 10 min, followed by the addition of DMF (1 mL).
The reaction mixture was stirred at room temperature for 60 min after which the solvent was removed in vacuo.
The residue was dissolved in THF (400 mL), then ammonium hydroxide (312 mL of a 25-28% aqueous solution) was added dropwise at 0° C.
The reaction mixture was allowed to warm to room temperature and was stirred for a further 60 min.
The THF was removed in vacuo and the residue was filtered.
The solid was collected, washed with water and dried to yield 8.66 g (87%) of the title compound. LCMS (ESI): [M+H]+=234/236.
References:
US2018/65983,2018,A1
698-67-9
164 suppliers
$12.00/5g
426265-73-8
44 suppliers
$55.00/250mg
154607-01-9
267 suppliers
$6.00/1g
426265-73-8
44 suppliers
$55.00/250mg