4-bromo-2-ethoxy-5-fluoropyridine synthesis
- Product Name:4-bromo-2-ethoxy-5-fluoropyridine
- CAS Number:1353776-96-1
- Molecular formula:C7H7BrFNO
- Molecular Weight:220.039
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Yield:-
Reaction Conditions:
with silver (II) carbonate in dichloromethane at 20;
Steps:
XLII 4-Bromo-2-ethoxy-5-fluororyridine
2.08 mL (26.0 mmol) Ethyl iodide and 1 .08 g (3.91 mmol) Ag2CO3 are added to a mixture of 500mg (2.160 mmol) 4-bromo-5-fluoro-pyridin-2-ol in 10 mL DCM. The mixture is stirred at r.t. over night. Then the reaction mixture is quenched by the addition of water and DCM. After filtration the org. layer is separated, dried with Na2SO4 and the solvent is removed in vacuo.C7H7BrFNO (M = 220.0 g/mol)ESI-MS: 220 [M+H]+ Rt (HPLC) : 1 .27 mm (method X)
References:
WO2013/92616,2013,A1 Location in patent:Page/Page column 103