4-Bromo-2-fluoro-3-methoxyaniline synthesis
- Product Name:4-Bromo-2-fluoro-3-methoxyaniline
- CAS Number:1272719-19-3
- Molecular formula:C7H7BrFNO
- Molecular Weight:220.04
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Yield: 98%
Reaction Conditions:
with N-Bromosuccinimide in N,N-dimethyl-formamide at 20; for 3 h;
Steps:
Preparation of compound 10[00177] To a solution of compound 9 (13 g, 92 mmol) in DMF (100 mL) was added a solution of NBS (16.4 g, 92 mmol, 1.0 eq) in DMF (100 mL) drop-wise. The reaction mixture was stirred at room temperature for 3h, then diluted with ethyl acetate (500 mL) and washed with brine (2xl50mL). The organic phase was dried (Na2S04), filtered and concentrated to give the title compound (10) as brown oil (23 g, 98%) yield). ESI-MS (M+H)+: 219.9.
References:
TONG, Youzhi WO2011/29392, 2011, A1 Location in patent:Page/Page column 57
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