4-bromo-3-(bromomethyl)-1-methyl-1H-pyrazole synthesis
- Product Name:4-bromo-3-(bromomethyl)-1-methyl-1H-pyrazole
- CAS Number:1383575-45-8
- Molecular formula:C5H6Br2N2
- Molecular Weight:253.9225
5775-82-6
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Yield:1383575-45-8 465 mg
Reaction Conditions:
with N-Bromosuccinimide;azobisisobutyronitrile in chlorobenzene at 80; for 7 h;
Steps:
0142-1 0142-1
0142-1
2,2'-Azobis(isobutyronitrile) (27 mg) was added to a solution of 4-bromo-1,3-dimethyl-1H-pyrazole (286 mg) and N-bromosuccinimide (320 mg) in chlorobenzene (6 mL), followed by stirring at 80° C. for 7 hours.
The reaction mixture was cooled to room temperature, and ethyl acetate and a saturated sodium hydrogen carbonate aqueous solution were added thereto.
The organic layer was collected by separation, washed with a saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure, thereby obtaining 4-bromo-3-(bromomethyl)-1-methyl-1H-pyrazole (465 mg) as a white solid.
MS m/z (M+H): 253.
References:
US2015/322063,2015,A1 Location in patent:Paragraph 0970; 0971; 0972
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