4-Bromo-3-methyl-isothiazole-5-carboxylic acid synthesis

4synthesis methods

Yield:-

Steps:

Multi-step reaction with 3 steps
1: LiAlH₄ / methanol; diethyl ether / 0 °C
2: aq. KOH
3: aq. NaHCO₃, Br₂

References:

Buttimore,D. et al. [Journal of the Chemical Society,1963,p. 2032 - 2039]

88511-32-4 Synthesis

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