(4-Bromo-3-methylphenyl)(methyl)sulphane synthesis

4synthesis methods

Product Name:(4-Bromo-3-methylphenyl)(methyl)sulphane
CAS Number:90532-02-8
Molecular formula:C8H9BrS
Molecular Weight:217.13

4886-77-5
33 suppliers
$595.00/100g

(4-Bromo-3-methylphenyl)(methyl)sulphane

90532-02-8
30 suppliers
$60.00/100mg

Yield:90532-02-8 97%

Reaction Conditions:

with bromine;acetic acid at 0 - 20;

Steps:

To a solution of 1-methyl-3-methanesulfanyl benzene (20 g, 145 mmol) in glacial acetic acid (68 ml_) was added bromine (12.5 ml_, 243.98 mmol) drop-wise at 0 °C. The reaction mixture was then allowed to warm up to room temperature and stirred for 4 hours. The solvent was evaporated under reduced pressure. Flash chromatography (J. T. Baker silica gel, 60-200 mesh, 100% hexane) gave 1 -bromo-4- methanesulfanyl-2-methyl benzene (30.5 g, 97%) as a clear, colorless oil.

References:

WO2010/55005,2010,A1 Location in patent:Page/Page column 76

452-63-1 Synthesis