4-broMo-5-chlorothiophene-2-carboxylic acid synthesis
- Product Name:4-broMo-5-chlorothiophene-2-carboxylic acid
- CAS Number:60729-37-5
- Molecular formula:C5H2BrClO2S
- Molecular Weight:241.49
16694-18-1
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60729-37-5
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$79.00/100mg
Yield: 79%
Reaction Conditions:
with N-chloro-succinimide in N,N-dimethyl-formamide at 50; for 10 h;
Steps:
89.a
To a solution of 4-bromo-2-thiophenecarboxylic acid (2.07 g, 10 mmol) in DMF (5 ml.) was added NCS (2.7 g, 15 mmol) in one portion. The reaction mixture was stirred at 50 0C for 10 h, and then cooled to room temperature. The desired product precipitated after water (5 ml.) was added. The white solid was filtered and dried under high vacuum to give 1.9 g (79%). LC-MS (ES) m/z =242 (M+H)+,
References:
SMITHKLINE BEECHAM CORPORATION WO2008/98104, 2008, A1 Location in patent:Page/Page column 177
24065-33-6
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60729-37-5
43 suppliers
$79.00/100mg
6310-09-4
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60729-37-5
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$79.00/100mg
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60729-37-5
43 suppliers
$79.00/100mg