4-bromo-5-methoxythiophene-2-carbaldehyde synthesis

Yield:-

Reaction Conditions:

with N-Bromosuccinimide in dichloromethane at 20;

Steps:

3-Bromo-5-formyl-2-methoxythiophene. 5-Formyl-2-methoxythiophene¹ (2.13 g) was dissolved in dichloromethane (20 mL) at room temperature and 7V-bromosuccinimide (3.2Og) was added. The mixture was stirred over night. The reaction was diluted with ether (50 mL) and extracted with water. The organic phase was dried (MgSO₄₎, filtered and evaporated. The crude product was purified by flash chromatography (gradient elution: 0 - 25% EtOAc in hexanes). Yield: 2.53 g. The identity of the compound was confirmed by mass spectrometry and NMR.

References:

WO2010/40839,2010,A1 Location in patent:Page/Page column 11