4-Bromo-N-(1,3-thiazol-2-yl)benzene-1-sulfonamide synthesis

Yield:331972-47-5 99%

Reaction Conditions:

with pyridine at 20; for 19 h;

Steps:

Method A A mixture of 4-bromobenzene-1-sulfonyl chloride (1 equivalent), amino heterocycle (1 equivalent) and pyridine (2.2-4.4 M) was stirred under an N₂ atmosphere at RT for 19 h. Purification via silica gel chromatography using 5% MeOH in CH₂Cl₂ gave the desired product.4-Bromo-N-(thiazol-2-yl)benzenesulfonamide Synthesised according to General procedure 1, Method A. Yield: 99%. ¹H NMR (400 MHz, DMSO-d6) δ 7.77-7.71 (m, 4H), 7.29 (d, J=4.6 Hz, 1H), 6.87 (d, J=4.6 Hz, 1H). LC/MS (10%-99% CH₃CN (0.035% TFA)/H₂O (0.05% TFA)), m/z: M+1 obs=319.0; t_R=3.22 min.

References:

US2009/124655,2009,A1 Location in patent:Page/Page column 15