ChemicalBook CAS DataBase List 4-(BROMOMETHYL)-4'-METHYL-2,2'-BIPYRIDINE

4-(BROMOMETHYL)-4'-METHYL-2,2'-BIPYRIDINE synthesis

5synthesis methods

Product Name:4-(BROMOMETHYL)-4'-METHYL-2,2'-BIPYRIDINE
CAS Number:81998-05-2
Molecular formula:C12H11BrN2
Molecular Weight:263.13

81998-04-1 Synthesis

4-HydroxyMethyl-4'-Methyl-2,2'-bipyridyl

81998-04-1
53 suppliers
$30.00/100mg

4-(BROMOMETHYL)-4'-METHYL-2,2'-BIPYRIDINE

81998-05-2
46 suppliers
$170.24/200MG

Yield:81998-05-2 93%

Reaction Conditions:

with sulfuric acid;hydrogen bromideReflux;

Steps:

1.2.2 Step 2.2

4-Hydroxymethyl-4'-methyl-2,2'-bipyridine (2.0 g, 10.0 mmol)Dissolve in HBr (48%, 40 mL) and add concentrated H2SO4 (10 mL) to the solution.The red solution was heated to reflux overnight, and after cooling to room temperature, the mixture was poured into 100 mL of ice water, and the pH value of the aqueous layer was adjusted to about 8.0 with Na2CO3,and extracted with chloroform until the organic layer was colorless, the combined organic layers were dried over MgSO4,The chloroform was removed by rotary evaporation in a vacuum to obtain 4-bromomethyl-4'-methyl-2,2'-bipyridine(2.4 g, 93%).

References:

CN114524853,2022,A Location in patent:Paragraph 0035-0036; 0040