4-Bromothiophene-2-carbonitrile synthesis
- Product Name:4-Bromothiophene-2-carbonitrile
- CAS Number:18791-99-6
- Molecular formula:C5H2BrNS
- Molecular Weight:188.05
18791-75-8
266 suppliers
$9.00/5g
18791-99-6
85 suppliers
$14.00/1g
Yield: 95%
Reaction Conditions:
Stage #1:4-Bromothiophen-2-aldehyde with hydroxylamine hydrochloride in pyridine at 90; for 0.166667 h;
Stage #2: with acetic anhydride in pyridine at 80; for 1 h;
Steps:
3.3 (3) 4 - bromo thiophene -2 - carbonitrile synthesis
The 4 - bromo thiophene -2 - formaldehyde (600g, 3.14 µM) and hydroxylamine hydrochloride (438g, 6.30 µM) added to the pyridine (5L) in, heated to 90° C10 minutes after cooling down to room temperature, drop vinegar anhydride (1940g, 19.0 µM) heated to 80 °C, reaction 1 hours, poured into water to (20L) in, stirring 30 minutes, filtered, drying to obtain the product (564g, yield 95%).
References:
Shandong Xuanzhu Pharmaceutical Technology Co., Ltd.;Wu Yongqian CN104230960, 2017, B Location in patent:Paragraph 0449; 0450; 0451
83933-17-9
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$11.00/100mg
18791-99-6
85 suppliers
$14.00/1g
31767-01-8
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$156.00/1g
18791-99-6
85 suppliers
$14.00/1g