4-Chloro-1,5-naphthyridine-3-carbonitrile synthesis

3synthesis methods

Product Name:4-Chloro-1,5-naphthyridine-3-carbonitrile
CAS Number:305371-02-2
Molecular formula:C9H4ClN3
Molecular Weight:189.6

4-hydroxy-1,5-naphthyridine-3-carbonitrile

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4-Chloro-1,5-naphthyridine-3-carbonitrile

305371-02-2
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Yield:305371-02-2 45%

Reaction Conditions:

with N,N-dimethyl-formamide;trichlorophosphate for 2 h;Inert atmosphere;Reflux;

Steps:

2.3 (3) Synthesis of intermediate CND - Cl

In a 50 ml round bottom flask in the two port, join the intermediate 2 - B (1.31 g, 9 mmol), N, N - dimethyl aniline (61 mg, 0.5 mmol) and 7 ml phosphorus oxychloride, under protection of argon reflux 2 hours. Cooling to room temperature, the reaction nearby fluid stirring and drip to the ice water, dichloromethane multiple extraction, the solvent is removed by rotary evaporator. Column chromatography purification and separation. To obtain white solid CND - Cl 0.77 g, yield 45%.

References:

CN109836422,2019,A Location in patent:Paragraph 0081; 0083; 0086; 0087

462-08-8 Synthesis

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References

2-Propenoic acid, 2-cyano-3-(3-pyridinylamino)-, ethyl ester

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References