4-chloro-1,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidine synthesis
- Product Name:4-chloro-1,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidine
- CAS Number:5413-96-7
- Molecular formula:C6H6ClN5
- Molecular Weight:183.6
![4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine](/CAS/GIF/98141-42-5.gif)
98141-42-5
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5413-96-7
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Yield:5413-96-7 85%
Reaction Conditions:
with ammonium hydroxide in tetrahydrofuran at 25; for 24 h;
Steps:
2 Step2: Amination
To a suspension of 4,6-Dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine (2.84g, 14 mmol) in the reaction flask and then add THF(56ml) to wait for the solid to dissolve completely. Then add 20g 30% ammonium solution and react at room temperature (25 °C) for 24h and poured 60ml water into the solution, filtration by suction to afford the 6-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (2.17g, 85%) as a yellow solid powder.
References:
WO2021/80980,2021,A1 Location in patent:Page/Page column 20
50270-27-4
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5413-96-7
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$80.00/500mg
5334-41-8
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5413-96-7
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![1-methyl-1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione](/CAS2/GIF/5401-15-0.gif)
5401-15-0
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5413-96-7
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