4-CHLORO-2-(2-FLUORO-PHENYL)-QUINAZOLINE synthesis
- Product Name:4-CHLORO-2-(2-FLUORO-PHENYL)-QUINAZOLINE
- CAS Number:610276-37-4
- Molecular formula:C14H8ClFN2
- Molecular Weight:258.68
138867-16-0
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Yield:610276-37-4 73%
Reaction Conditions:
with thionyl chloride;N,N-dimethyl-formamide in chloroform at 0 - 80; for 4 h;
Steps:
1.C Step C: Preparation of 4-CHLORO-2- (2-FLUORO-PHENYL)- quinazoline
2-(2-FLUORO-PHENYL)-3H-QUINAZOLIN-4-ONE from Step B (0.86g, 3. 5MMOL) was suspended in chloroform in a 50ML round bottomed flask equipped with magnetic stirrer. The flask was cooled to 0°C and to it was added thionyl chloride (1. 2ml) drop wise followed by N, N-DIMETHYLFORMAMIDE (0. 01ML) and the mixture heated to 80°C for 4HRS. The solvent was removed by evaporation in a rotary evaporator to leave a title compound as a solid (0. 68G, 73%). MS (ES) 259.1 (M+H) +
References:
WO2004/81009,2004,A1 Location in patent:Page 44-45
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