4-CHLORO-2-PHENYL-7H-PYRROLO[2,3-D]PYRIMIDINE synthesis

Yield:-

Reaction Conditions:

with trichlorophosphate for 5 h;Heating / reflux;

Steps:

C

2-phenyl-pyrrolo[2,3d]pyrimidinone (1.0 g 4.73 mmol) was treated with phosphorous oxychloride (7 ml, 27.7 mmol) and refluxed for 5 hrs. Excess phosphorous oxychloride was removed under reduced pressure and then extracted with chloroform, washed with sodium bicarbonate. The organic layer was dried over sodium sulfate(anh), then concentrated to dryness to give the product

References:

WO2006/35061,2006,A1 Location in patent:Page/Page column 31; 32