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133092-34-9

4-Chloro-5,6,7,8-tetrahydroquinoline synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: nickel; methanol; sodium acetate contain. acetic acid / 120 °C / 73550.8 Torr / Hydrogenation
2: sodium nitrite; sodium hypophosphite
3: phosphorus (V)-chloride; phosphoryl chloride / 130 °C

References:

Ishii [Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1952,vol. 72,p. 1317,1320][Chem.Abstr.,1953,p. 12386]