4-CHLORO-5-IODO-6-METHYLPYRIMIDINE synthesis
- Product Name:4-CHLORO-5-IODO-6-METHYLPYRIMIDINE
- CAS Number:83410-15-5
- Molecular formula:C5H4ClIN2
- Molecular Weight:254.46
7752-74-1
41 suppliers
$23.00/100mg
83410-15-5
45 suppliers
$56.00/50mg
Yield:83410-15-5 93%
Reaction Conditions:
with trichlorophosphate at 90; for 1 h;Neat (no solvent);
Steps:
A suspension of 90 g (0.38 mol) 4-hydroxy-5-iodo-6-methyl pyrimidine in 600 mL POCI3 is heated for 1 h at 90 °C. The reaction mixture is concentrated under reduced pressure and the residue is poured into crushed ice. The precipitated solid is collected by filtration and washed with water. After drying, the desired product is obtained as a solid (90 g; 93 %).
References:
WO2011/92197,2011,A1 Location in patent:Page/Page column 22
7752-74-1
41 suppliers
$23.00/100mg
83410-15-5
45 suppliers
$56.00/50mg
56-04-2
358 suppliers
$5.00/100mg
83410-15-5
45 suppliers
$56.00/50mg
3524-87-6
181 suppliers
$29.00/1g
83410-15-5
45 suppliers
$56.00/50mg
3524-87-6
181 suppliers
$29.00/1g
83410-15-5
45 suppliers
$56.00/50mg