4-Chloro-5-Methoxy-2-(2-pyridyl)pyriMidine, 97% synthesis
- Product Name:4-Chloro-5-Methoxy-2-(2-pyridyl)pyriMidine, 97%
- CAS Number:321432-82-0
- Molecular formula:C10H8ClN3O
- Molecular Weight:221.64
321432-75-1
17 suppliers
$321.64/1gm:
321432-82-0
28 suppliers
$194.00/250mg
Yield:321432-82-0 94%
Reaction Conditions:
with trichlorophosphate for 1.5 h;Reflux;
Steps:
H2-1.2
5 g (25 mmol) of compound B-2-1 are mixed with 40 g phosphoryl chloride and the mixture is heated for 90 minutes to reflux. The excess POCl3 is removed by distillation. Cooling is performed and the residue mixed with dichloromethane. Hydrolysis with water is performed and the formulation adjusted with NaOH to form an alkaline. The organic phase is separated and the aqueous phase extracted a further twice with dichloromethane. The combined organic phases are dried by means of sodium sulphate, filtered and rotated on the rotary evaporator.Yield: 94%1H-NMR (CDCl3): d 8.82; s 8.47; d 8.42; tr 7.85; m 7.36-7.41; s 4.08 [ppm]
References:
US2012/263659,2012,A1 Location in patent:Page/Page column 48
321432-75-1
17 suppliers
$321.64/1gm:
321432-82-0
28 suppliers
$194.00/250mg
100-70-9
428 suppliers
$13.00/25g
321432-82-0
28 suppliers
$194.00/250mg