ChemicalBook CAS DataBase List 4-CHLORO-6-FLUORO-QUINOLINE-3-CARBONITRILE

4-CHLORO-6-FLUORO-QUINOLINE-3-CARBONITRILE synthesis

4synthesis methods

Product Name:4-CHLORO-6-FLUORO-QUINOLINE-3-CARBONITRILE
CAS Number:886362-73-8
Molecular formula:C10H4ClFN2
Molecular Weight:206.6

446-08-2 Synthesis

446-08-2
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4-CHLORO-6-FLUORO-QUINOLINE-3-CARBONITRILE

886362-73-8
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Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: benzine; methanol; hexane / 0 - 20 °C
2.1: methanol / 1 h / 150 °C / Microwave irradiation; Sealed tube
3.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C
3.2: 1 h / -78 °C
3.3: -78 - 20 °C
4.1: trichlorophosphate / 0.5 h / 100 °C

References:

Reed, Carson W.;Kalbfleisch, Jacob J.;Wong, Madison J.;Washecheck, Jordan P.;Hunter, Ashton;Rodriguez, Alice L.;Blobaum, Anna L.;Conn, P. Jeffrey;Niswender, Colleen M.;Lindsley, Craig W. [ACS Medicinal Chemistry Letters,2020,vol. 11,# 9,p. 1773 - 1779]

319-24-4 Synthesis

2-Amino-5-fluorobenzoic acid methyl ester

319-24-4
145 suppliers
$8.00/1g

886362-73-8
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References

6-Fluoro-4-hydroxyquinoline-3- carbonitrile

71083-60-8
7 suppliers
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886362-73-8
41 suppliers
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References

2-Propenoic acid, 2-cyano-3-[(4-fluorophenyl)amino]-, ethyl ester

326915-70-2
2 suppliers
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886362-73-8
41 suppliers
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References

4-CHLORO-6-FLUORO-QUINOLINE-3-CARBONITRILE Related Search:

2-Fluoro-6-formylpyridine 2-FLUORO-6-HYDROXYMETHYL PYRIDINE 6-FLUORO-3-IODO (1H)INDAZOLE 6-Fluoro-4,4-diMethyl-1,3-dihydroquinolin-2-one 4-Chloro-6-fluoroquinoline