4-CHLORO-6-FLUOROPYRIDO[3,4-D]PYRIMIDINE synthesis
- Product Name:4-CHLORO-6-FLUOROPYRIDO[3,4-D]PYRIMIDINE
- CAS Number:175357-98-9
- Molecular formula:C7H3ClFN3
- Molecular Weight:183.57
![6-FLUOROPYRIDO[3,4-D]PYRIMIDIN-4-OL](/CAS/GIF/171178-44-2.gif)
171178-44-2
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$200.00/50mg
175357-98-9
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$366.00/100mg
Yield: 100%
Reaction Conditions:
with thionyl chloride in DMF (N,N-dimethyl-formamide) for 7 h;Heating / reflux;
Steps:
A.6.a
DMF (5 drops) was added to a mixture of 6-Fluoro-3H-pyrido [3,4-d] pyrimidin-4-one (0.00605 mol) and thionyl chloride (0.39 mol). The reaction mixture was stirred and refluxed (at 80 C) for 7 hours. The solvent was evaporated, yielding 1.254 g of intermediate (12) (impure quantitative yield; used in next reaction step, without further purification).
References:
JANSSEN PHARMACEUTICA N.V. WO2005/58913, 2005, A1 Location in patent:Page/Page column 38
171178-43-1
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$33.00/100mg
175357-98-9
74 suppliers
$366.00/100mg
171178-41-9
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$37.00/100mg
175357-98-9
74 suppliers
$366.00/100mg
1827-27-6
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$5.00/1g
175357-98-9
74 suppliers
$366.00/100mg
171178-42-0
44 suppliers
$122.00/50mg
175357-98-9
74 suppliers
$366.00/100mg