4-Chloro-N-(4-chlorobenzyl)benzaMide, 97% synthesis
- Product Name:4-Chloro-N-(4-chlorobenzyl)benzaMide, 97%
- CAS Number:130780-10-8
- Molecular formula:C14H11Cl2NO
- Molecular Weight:280.15
Yield:-
Reaction Conditions:
with triethylamine in dichloromethane at 20 - 25; for 4 h;
Steps:
Preparation of N-Benzyl-4-methoxybenzamide
General procedure: One drop of dry N,N-dimethyl formamide and oxalyl chloride (0.62 g, 4.9 mmol) were addeddropwise to a solution of 4-methoxybenzoic acid (0.50 g, 3.3 mmol) in dry CH2Cl2 (20 mL). The reactionmixture was stirred at room temperature for 2 h, and then distilled in vacuo to give the crude acylchloride, which was dissolved in dry CH2Cl2 (10 mL). Dry triethylamine (0.40 g, 3.9 mmol) was addedto a solution of benzylamine (0.35 g, 3.3 mmol) in dry CH2Cl2 (20 mL). The reaction mixture wascooled to 0 °C, and the acyl chloride solution was added dropwise. After stirring at 20-25 °C for 4 h,the reaction mixture was distilled in vacuo, and washed with a 10% solution of NaOH and water,and dried. Silica gel column chromatography (hexane/ethyl acetate) afforded I-1 as a white powder(0.75 g, 94.8% yield).
References:
Wen, Hui;Qin, Wen;Yang, Guangzhong;Guo, Yanshen [Molecules,2019,vol. 24,# 3,art. no. 497;]
74-11-3
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