4-chlorobenzo[4,5]thieno[2,3-d]pyriMidine synthesis
- Product Name:4-chlorobenzo[4,5]thieno[2,3-d]pyriMidine
- CAS Number:40142-92-5
- Molecular formula:C10H5ClN2S
- Molecular Weight:220.68
![benzo[4,5]thieno[2,3-d]pyriMidin-4-ol](/CAS/20150408/GIF/18774-49-7.gif)
18774-49-7
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40142-92-5
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$285.00/100mg
Yield:40142-92-5 74%
Reaction Conditions:
with trichlorophosphateReflux;
Steps:
S.8 General method for the preparation of 4-chloro-thieno[2,3-d]pyrimidines 7a-d, f-i
General procedure: The different thieno[2,3-d]pyrimidin-4-one (6a-d or f-i) (1 eq.) and phosphoryl chloride (2.9 mL/mmoleq.) were refluxed for 8 h. The reaction mixture was then cooled in an ice-bath and carefully neutralised by the addition of aqueous saturated NaHCO3 solution. The resulting mixture was extracted with ethylacetate (15 mL/mmol eq.), the organic layer was separated, dried over MgSO4 and concentrated. The crude residue was purified by flash column chromatography eluting with n-hexane-EtOAc 100:0 v/vincreasing to n-hexane-EtOAc 85:15 v/v unless otherwise stated.
References:
Bassetto, Marcella;Leyssen, Pieter;Neyts, Johan;Yerukhimovich, Mark M.;Frick, David N.;Brancale, Andrea [European Journal of Medicinal Chemistry,2016,vol. 123,p. 31 - 47] Location in patent:supporting information
18774-49-7
13 suppliers
inquiry
40142-92-5
9 suppliers
$285.00/100mg
7311-95-7
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$89.00/100mg
40142-92-5
9 suppliers
$285.00/100mg
![ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE](/CAS/GIF/4506-71-2.gif)
4506-71-2
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40142-92-5
9 suppliers
$285.00/100mg
108-94-1
569 suppliers
$12.00/50g
40142-92-5
9 suppliers
$285.00/100mg