4-Chlorophenethyl iodide synthesis
- Product Name:4-Chlorophenethyl iodide
- CAS Number:57186-64-8
- Molecular formula:C8H8ClI
- Molecular Weight:266.51
1875-88-3
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Yield:57186-64-8 96%
Reaction Conditions:
with 1H-imidazole;iodine;triphenylphosphine in dichloromethane at 0 - 20; for 1.16667 h;Inert atmosphere;
Steps:
Alkyl Iodides 4; General Procedure A
General procedure: To a solution of the appropriate alcohol (1.0 equiv) in CH2Cl2 (0.5 M), imidazole (1.2 equiv), PPh3 (1.1 equiv), and iodine (1.1 equiv) were sequentially added at 0 °C. After completion of the addition, the mixture was stirred at 0 °C for 10 min. The resulting mixture was warmed to r.t. and stirred for 1 h. The reaction was quenched by sat. aq Na2S2O3. The organic layer was separated and dried over anhydrous Na2SO4. After the solvent had been removed in vacuo, the crude product was purified by flash column chromatography (silica gel, hexane/EtOAc) to give the corresponding alkyl iodide 4.
References:
Kojima, Masahiro;Matsunaga, Shigeki [Synthesis,2020,vol. 52,# 13,p. 1934 - 1946]
6529-53-9
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1878-66-6
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52449-43-1
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2019-34-3
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