4-chlorophenyl salicylate synthesis
- Product Name:4-chlorophenyl salicylate
- CAS Number:2944-58-3
- Molecular formula:C13H9ClO3
- Molecular Weight:248.66
444-30-4
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106-48-9
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2944-58-3
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$106.00/250mg
Yield:2944-58-3 91%
Reaction Conditions:
with water;potassium carbonate in toluene at 120; for 12 h;
Steps:
2. General procedure for the reaction
General procedure: 1 (0.2 mmol, 1.0 equiv.), 2 (0.24mmol, 1.2 equiv.), K2CO3 (0.4 mmol, 2.0 equiv.), and toluene/H2O (V/V = 95:5, 2.0 mL) were added to a test tube at 120 °C in an oil bath under air overnight. After the disappearance of the substrate as indicated by TLC, the mixture was extracted by DCM (3 × 5 mL). The organic layers were combined and dried by Na2SO4. The solvent was removed under vacuum and the residue was purified by silica gel chromatography, using a mixture of petroleum ether/ethyl acetate to give the desired product 3.
References:
Lin, Chuankai;Liu, Jin-Biao;Wang, Ruixiang;Xie, Huilin [Tetrahedron Letters,2022,vol. 89,art. no. 153592] Location in patent:supporting information
104316-24-7
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69-72-7
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2944-58-3
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$106.00/250mg
6410-65-7
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2944-58-3
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111826-11-0
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2944-58-3
17 suppliers
$106.00/250mg
106-48-9
494 suppliers
$10.00/5G
69-72-7
1308 suppliers
$5.00/10g
2944-58-3
17 suppliers
$106.00/250mg