4-Cyano-2,6-dimethoxyphenol synthesis
- Product Name:4-Cyano-2,6-dimethoxyphenol
- CAS Number:72684-95-8
- Molecular formula:C9H9NO3
- Molecular Weight:179.17
134-96-3
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Yield:72684-95-8 98%
Reaction Conditions:
with acetic acid;hydroxylamine-O-sulfonic acid in water at 50; for 6 h;
Steps:
General method for the synthesis of nitriles
General procedure: In a 10 mL round bottom flask at 0 °C, aldehyde (1.0 mmol, 1.0 equiv) and NH2OSO3H (1.1 mmol, 1.1 equiv) were dissolved in 4 mL of H2O with acetic acid (1.0 mmol, 1 equiv). The reaction was stirred at 50 °C for 6 h or until complete conversion by TLC. The reaction was quenched with aqueous 10% NaHCO3 (1 mL) and the resulting mixture was extracted with EtOAc (3*10 mL), dried (Na2SO4), filtered, and concentrated by rotary evaporation to afford the crude product. The product was directly characterized unless traces of impurities required purification by automated silica gel flash chromatography (three examples).
References:
Quinn, Dylan J.;Haun, Graham J.;Moura-Letts, Gustavo [Tetrahedron Letters,2016,vol. 57,# 34,p. 3844 - 3847] Location in patent:supporting information
1885-35-4
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5032-13-3
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54738-29-3
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2973-77-5
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