4-Cyclopropylpyridin-3-amine synthesis
- Product Name:4-Cyclopropylpyridin-3-amine
- CAS Number:1365763-16-1
- Molecular formula:C8H10N2
- Molecular Weight:134.18
1365763-14-9
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1365763-16-1
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$192.00/250mg
Yield:1365763-16-1 100%
Reaction Conditions:
with ammonium chloride;zinc in tetrahydrofuran at 0 - 20;
Steps:
73 Preparation of Intermediate 4-cyclopropylpyridin-3-amine (I-73b)
Preparation of Intermediate 4-cyclopropylpyridin-3-amine (I-73b)
Zinc powder (223.2 mg, 3.41 mmol) and ammonium chloride solution (365 mg, 6.8 mmol) were added to a stirred solution of 4-cyclopropyl-3-nitropyridine (70 mg, 0.426 mmol) in dry THF (2 mL) at 0° C. and the resulting mixture was stirred at room temperature for 1 hour.
The reaction was monitored by TLC (10% methanol in CHCl3).
The organic layer was concentrated and washed with pentane to afford 450 mg of the product (100% yield).
1H NMR (CDCl3, 300 MHz): δ 8.10 (s, 1H), 7.95 (d, 1H), 6.90 (d, 1H), 4.1 (bs, 2H), 1.75-1.60 (m, 1H), 1.10-0.95 (q, 2H), 0.70-0.60 (q, 2H). LCMS: 84.5%, m/z=135.1 (M+1)
References:
US2014/45872,2014,A1 Location in patent:Paragraph 1071
20511-15-3
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411235-57-9
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1365763-16-1
17 suppliers
$192.00/250mg
13091-23-1
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1365763-16-1
17 suppliers
$192.00/250mg