4-Ethoxy-2,6-difluorobenzoyl chloride, 97% synthesis
- Product Name:4-Ethoxy-2,6-difluorobenzoyl chloride, 97%
- CAS Number:1373920-79-6
- Molecular formula:C9H7ClF2O2
- Molecular Weight:220.6
916483-56-2
21 suppliers
$61.00/1g
1373920-79-6
11 suppliers
$32.20/250mg
Yield:-
Reaction Conditions:
with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 20; for 4 h;
Steps:
2.ii.c
Oxalylchloride (3.17ml, 36.4mmol) was added dropwise to a stirred suspension of 4- ethoxy-2,6-difluorobenzoic acid (3.5g, 17.3mmol) and dimethylformamide (5 drops) in dichloromethane (50ml). The resulting solution was stirred at room temperature for 4 hours and was then evaporated. The residue was dissolved in tetrahydrofuran and then added dropwise to a vigorously stirring 35% aqueous ammonia solution (60ml). The mixture was filtered and the residue was washed with ice-cold water and then dried under vacuum to leave 4-ethoxy-2,6-difluorobenzamide as a colourless solid (3.23g, 93% yield):1H-NMR (DMSO d6): 7.91 (br. s, IH), 7.65 (br. s, IH), 6.78-6.71 (m, 2H), 4.08 (q, 2H), 1.32(t, 3H).MS (+ve EI) : 201 (M'+)
References:
WO2006/129064,2006,A1 Location in patent:Page/Page column 36
144891-25-8
12 suppliers
$58.00/500mg
1373920-79-6
11 suppliers
$32.20/250mg
2713-34-0
408 suppliers
$5.00/1g
1373920-79-6
11 suppliers
$32.20/250mg