4'-Ethoxy-3'-(trifluoroMethyl)acetophenone, 97% synthesis
- Product Name:4'-Ethoxy-3'-(trifluoroMethyl)acetophenone, 97%
- CAS Number:851263-13-3
- Molecular formula:C11H11F3O2
- Molecular Weight:232.2
208173-24-4
129 suppliers
$10.00/2g
851263-13-3
14 suppliers
$77.09/1g
Yield:851263-13-3 98%
Reaction Conditions:
with potassium ethoxide in ethanol at 20 - 60; for 2 h;
Steps:
A.2
Example A.2 4-Ethoxy-3-trifluoromethyl-acetophenone To a stirred suspension of potassium ethanolate (2.36 g, 27 mmol) in ethanol (30 ml) was added at room temperature a solution of 4-fluoro-3-trifluoromethyl-acetophenone (2.5 g, 12 mmol) in ethanol (10 ml). The reaction mixture was stirred at 60° C. for 2 h and evaporated. Ice/2 N HCl (50 ml) was added and the water layer was extracted with diethylether (2*100 ml). The combined organic layers were washed with ice-water (50 ml), brine (50 ml), dried (MgSO4) and evaporated to give the title compound (2.9 g, 98%) as a brown solid, which was used without further purification. MS (EI) 232.1 [M].
References:
US2006/183756,2006,A1 Location in patent:Page/Page column 10
917-58-8
120 suppliers
$71.00/100g
208173-24-4
129 suppliers
$10.00/2g
851263-13-3
14 suppliers
$77.09/1g
149105-11-3
74 suppliers
$25.00/250mg
75-03-6
369 suppliers
$11.00/5g
851263-13-3
14 suppliers
$77.09/1g