(4-fluoro-2-methylphenyl)hydrazine synthesis

Yield:439863-62-4 48%

Reaction Conditions:

Stage #1: 4-fluor-2-methylanilinewith hydrogenchloride;sodium nitrite in water at 0; for 2 h;
Stage #2: with tin(ll) chloride in water at 0 - 20; for 12 h;

References:

Hasui, Tomoaki;Matsunaga, Nobuyuki;Ora, Taiichi;Ohyabu, Norio;Nishigaki, Nobuhiro;Imura, Yoshimi;Igata, Yumiko;Matsui, Hideki;Motoyaji, Takashi;Tanaka, Toshimasa;Habuka, Noriyuki;Sogabe, Satoshi;Ono, Midori;Siedem, Christopher S.;Tang, Tony P.;Gauthier, Cassandra;De Meese, Lisa A.;Boyd, Steven A.;Fukumoto, Shoji [Journal of Medicinal Chemistry,2011,vol. 54,# 24,p. 8616 - 8631] Location in patent:experimental part