4-Fluoro-n1-methylbenzene-1,2-diamine synthesis
- Product Name:4-Fluoro-n1-methylbenzene-1,2-diamine
- CAS Number:401567-10-0
- Molecular formula:C7H9FN2
- Molecular Weight:140.16
704-05-2
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401567-10-0
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$55.00/250mg
Yield:401567-10-0 50%
Reaction Conditions:
with hydrogen;palladium-on-charcoal in ethanol; under 3000.3 Torr;
Steps:
b
b) 4-fluoro-N-1-methyl-benzene-1,2-diamine: 22 g (0.12 mol) (4-fluoro-2-nitro-phenyl)-methyl-amine in 250 mL ethanol are hydrogenated at 4 bar hydrogen pressure with palladium on charcoal as catalyst. The catalyst is separated off and the solvent is distilled off. The oil remaining is purified by chromatography (silica gel, hexane/ethyl acetate gradient). Yield: 9 g (50%); mass spectroscopy [M+H]+=141.
References:
US2007/249595,2007,A1 Location in patent:Page/Page column 10
364-74-9
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401567-10-0
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131780-97-7
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362670-06-2
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362670-07-3
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401567-10-0
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