4-HYDRAZINO 8-TRIFLUOROMETHYL-QUINOLINE synthesis
- Product Name:4-HYDRAZINO 8-TRIFLUOROMETHYL-QUINOLINE
- CAS Number:57369-92-3
- Molecular formula:C10H8F3N3
- Molecular Weight:227.19
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Yield:-
Reaction Conditions:
with (R)-(-)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyl di-t-butylphosphine;bis(tri-ortho-tolylphosphine)palladium(0);potassium hydroxide;hydrazine in 1,4-dioxane at 100; for 8 h;
Steps:
1 Step 1
4-chloro-8-(trifluoromethyl)quinolone was reacted with 2 equivalents of hydrazine in 5% mol PD[P(o-tolyl)3]2, CyPF-tBu, potassium hydroxine, dioxane at 100 °C for 8 hours to produce 4-hydrazineyl-8-(trifluoromethyl)quinoline.
References:
WO2021/146341,2021,A1 Location in patent:Paragraph 0101; 0103
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