4-hydroxy-2-Piperidinone synthesis
- Product Name:4-hydroxy-2-Piperidinone
- CAS Number:476014-76-3
- Molecular formula:C5H9NO2
- Molecular Weight:115.13
50607-30-2
476014-76-3
Step 1) NaBH4 (1 g, 26.55 mmol) was slowly added to a solution of piperidine-2,4-dione (1 g, 8.8 mmol) in methanol (25 mL) at 0°C. The reaction mixture was stirred at room temperature overnight before the solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol, 5:1, v/v) to afford 4-hydroxy-2-piperidone as a yellow solid (960 mg, 87% yield). m/z by LC-MS (ESI, positive ion mode): 138 [M + Na]+.
50607-30-2
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476014-76-3
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Yield:476014-76-3 87%
Reaction Conditions:
with methanol;sodium tetrahydroborate at 0 - 20;
Steps:
16.1 Step 1) 4-hydroxypiperidin-2-one
Step 1) 4-hydroxypiperidin-2-one [0258] To a solution of piperidine-2,4-dione (1 g, 8.8 mmol) in MeOH (25 mL) was added NaBH4 (1 g, 26.55 mmol) at 0°C. The reaction was stirred at rt overnight, then concentrated in vacuo. The residue was purified by a silica gel column chromatography (DCM/MeOH (v/v) = 5/1) to give the title compound as ayellow solid (960 mg, 87%). LC-MS (ESI, pos. ion) m/z: 138[M + Na]+.
References:
XI, Ning;WANG, Tingjin;YI, Lei WO2013/138210, 2013, A1 Location in patent:Paragraph 0258
158849-52-6
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476014-76-3
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$24.00/100mg
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476014-76-3
123 suppliers
$24.00/100mg