4-Hydroxy-4-phenylcyclohexanone synthesis

10synthesis methods

Product Name:4-Hydroxy-4-phenylcyclohexanone
CAS Number:51171-73-4
Molecular formula:C12H14O2
Molecular Weight:190.24

94112-58-0 Synthesis

94112-58-0
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51171-73-4
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Yield:51171-73-4 98%

Reaction Conditions:

with hydrogenchloride in tetrahydrofuran;water at 25; for 16 h;

Steps:

192.B Step B: 4-Hydroxy-4-phenylcyclohexan-1-one.

To a solution of 8-phenyl-1,4- dioxaspiro[4.5]decan-8-ol (300 mg, 1.28 mmol) in THF (3 mL) was added HCl (3 mL,10% HCl in water). The reaction was stirred at 25°C for 16 hr. The reaction mixture was poured into water (10 mL) and extracted with ethyl acetate (5 mL x 3). The combined organic extracts were washed with brine (10 mL), dried over anhydrous sodium sulfate, filtered, and concentrated to dryness under reduced pressure to give the title compound (240 mg, 98%) as a white solid

References:

WO2022/165529,2022,A1 Location in patent:Page/Page column 233

4746-97-8 Synthesis